We spent 4 nights here and this was our second stay in the past two years. As a tourist we find the location to be super and the main reason we chose the Mayflower. We took light rail from the airport to the end (Westlake Center) and walked to the hotel lobby from a "Hotel Entrance" hall in the Center. Couldn't be more convenient. It would be better if every day they didn't have the entrance blocked off in the hotel due to special functions.
The rooms have everything one could want except for a small refrigerator. We take a Queen (only size beds here) Deluxe and highly recommend room 1221 - it has pocket doors separating the bedroom from the "living room".
We really like the restaurant and the cocktail lounge and ate breakfast and dinner in one or the other. The locals fill them up so it must be popular.