Girl Scout Troop Leaders - this is a perfect hotel.
The suites sleep 6 people (2 Queen beds & a double sleeper), rates are very reasonable/budget-friendly and allow girls to socialize while meeting your adult/girl ratios. They will also do their best to book your rooms on the same floor or next to each other.
Breakfast was great. I had read about the waffle iron and this was a hit with the girls. The only drawback is that it's so popular you may have to wait in line to make one. There are several other choices on the menu as well.
The area is safe and though not very central to the historic district, everything is within walking distance. You just need to plan your activities ahead and you'll be fine. We didn't need our cars for anything except our visit to Bonaventure Cemetery.