We returned today from a four night stay at the Best Western Seaport Inn. We found this hotel to be in a wonderful, quaint location in excellent proximity to all that lower Manhattan has to offer. We had a large, very clean and comfortable double room with 5 big windows and a stellar view of the Brooklyn Bridge. The breakfast was nothing special, but it was free and perfect for my family to start the day.
If a quiet location, that is a bit "off the beaten path" is what you are after, the Best Western Seaport Inn is a lovely and relatively economical choice. I would recommend it!