My wife and I stayed at at A Garden In Chelsea for 11 nights over Christmas and New Years in December 2012 and thoroughly enjoyed the experience.
It was our first time staying at a B&B so were a little unsure what to expect but after spending the previous 3 weeks in hotels it was a very welcome change. Karen and Paul the hosts were very accommodating and friendly and were always willing for a quick chat when we ran into them.
The room itself was in then basement which gave it a very cosy and homely charm. It has a private kitchen and small dining area as well as a bathroom. It's quite large compared to Manhatten standards. After extremely busy days exploring the sights of NYC it was nice to return home to our own little haven.
Perfect location in the heart of Chelsea with an abundance of restaurants close by, as well a walking distance to the famed Chelsea Markets and the Subway. It was nice to get away from the hotel scene and we actually felt a little like 'locals' staying at the Garden.
I hope to return to NYC in the coming years and this place will be the first thing I book.