I recently stayed at The Bowery Hotel for 6 days for Fashion Week. I stayed in a standard queen on the 11th floor. It was really lovely, the rugs are pretty, the lighting is great and the views were stunning. It really was a pleasure getting back to my room everyday. I had everything I needed and even though it was small I was very happy. The bar is one of my favorites and even though it is buzzing downstairs, the room was quiet. I couldn't have enjoyed it more!
I don't think the queen would be good for two people. I would definitely recommend this hotel over the Soho Grand, Dream Downtown and Standard. There is no comparison really.
I would definitely stay there again. Also the mini bar is very well stocked for the modern traveler.