I highly recommend Duane STreet Hotel in Tribeca. It is located close to restaurants, business and government institutions, as well as almost all of the subway lines. The hotel is new, modern, clean, minimalist and operates exceptionally well. I stayed for 10 days for business, and I had NO complaints during the entire 10 days stay. The hotel was quiet, comfortable and located close to anything I could want. The staff was not only super competent, but every single staff person I encountered was exceptionally friendly and eager to help. I would love to stay there agian on my next trip to NY.