Just returned from a week's stay at the Lex NYC, and it was a fantastic experience all round. The room was of a decent size, and spotlessly clean.
The hotel staff were all very friendly and helpful and made us feel welcome, offering advice on airport transports, places to eat and drink and the like.
Location wise it is exactly what we wanted, mid-town Manhattan meaning you are very well connected and a short ride away from most attractions, and it is a fairly cheap and straightforward journey using public transport to JFK.
Would definitely return.