We live nearby and brought our family (2 adults, 2 young children) to the Wyndham Garden Chinatown twice while some work was being done on our apartment. We chose it because the "queen suite" could accommodate our whole family for less than the price of two rooms at any other hotel within walking distance of our son's school.
First the good: Our "queen suite" (room 607 the first stay; 606 the second stay) was reasonably spacious by Manhattan standards and very clean. There is a mini-fridge you can actually use (not a minibar), reliable free wifi, and the room and bathroom had a nice modern design (we looked at some of the same fixtures when we renovated our apartment). The staff at the front desk was extremely friendly and tried hard to be helpful. I also think the location is very good for anybody with business in Chinatown and excellent for tourists who are looking for a more interesting place to stay than the typical tourist mega-hotels in Midtown (walkable to many interesting neighborhoods, and good subway access to the rest of the city).
But there are some significant drawbacks to this property.
The hotel is very new. I believe it opened in November 2012. But it appears to have been cheaply built. Our first room had some water stains on the ceiling near the windows, indicating there had probably been a leak at some point. Our room on the second visit had a desk lamp that barely put out any light, a semi-broken temperature control in the shower, and a sink that filled faster than it could drain.
There were also a number of bizarre design decisions. The "suite" is a big square room with a full wall of floor-to-ceiling windows and an L shaped wall that divides the room into three areas.
The L wall runs parallel to the windows and turns into the room to create a bed area. The bed area was barely larger than the bed itself and completely walled off from the windows, but the bed was comfortable.
Between the wall and the windows, there is a mostly wasted space where they've put an upholstered chair (that I can't imagine anybody ever uses) and a desk. The desk thoughtfully has open electrical outlets at desk level for plugging in computers and phone chargers, but lacks a phone. In both suites I had to unplug the phone from the bedside nightstand and plug it into the desk (which at least has a jack) to make phone calls while working at the desk. But at least local calls were free, and the hotel's free wifi worked well with my computer.
The rest of the room is a living area. There is an incredibly uncomfortable (for sitting or sleeping) pullout couch. Unlike most hotels with pullout couches, the mattress comes bare and you have to request sheets. And the pullout is very small--not even close to the length of a regular bed. It was fine for our 5 year old, but I would NOT recommend it for a full grown adult. There's also a very high marble table with barstool-like seating that looked cool and was okay for eating meals, but precarious for our 2 year old.
The mini-fridge is enclosed in a cabinet that has no ventilation, so unless you leave the cabinet open, the fridge is engaged in a Sisyphean battle against its own heat production.
The bathroom has a nice aesthetic, but doesn't have a bathtub (shower only, with weak water pressure and the aforementioned semi-broken control in one of our two rooms), has very little counter space (although there are shelves below the sink) and nowhere to hang wet towels, and has a translucent door that allows people in the room to see the silhouette of someone sitting on the toilet.
The wall of windows had an intresting view from our 6th floor rooms and had effective privacy and blackout curtains, but none of the windows open. Given the hotel's location a block from the entrance to the Manhattan Bridge, that's not necessarily a bad thing (the air outside is likely worse than the hotel's recirculated air, and the windows are very well soundproofed against the sometimes cacophonous traffic), but for some people the lack of open-able windows can be a deal breaker.
The hotel's service was okay, but not great. It took three calls on our second visit to get sheets for the pullout couch. But they're very friendly, keep the place very clean, and provide nice freebies like a crib for the 2 year old.
All in all, I'd consider returning if the price is right, but would only recommend it to folks who need a cheap suite in the area or who want a reasonably priced modern hotel in a fun neighborhood and don't mind the quirky details.