We booked this because of the location. It turned out to be convenient, but we didn't really care for the gaslamp district (too much of a frat party vibe), but the hotel was not so close to that area to be annoying. As others have noted, you do hear drunk people yelling on the street late at night.
Otherwise, the room was clean and spacious (we had a superior king room on the corner). The staff was very friendly and helpful. It was easy to walk to places, and also easy to get on the highway for driving up to La Jolla or other spots.
It was a good value, and if you want to stay downtown, it seems like a great choice.