Stayed at the Hyatt Grand for 10 days recently and was really impressed with the great location overlooking the bay and within walk of the Gaslight area and the Midway and other downtown attractions.
The rooms (i had a king in the Harbor Tower) are modern with a nice desk area and settee and superb view over the bay and the softest pillows I have ever had in a hotel.
Quality service from the concierge through to the excellent bar staff. Across the road is a small hopping complex that includes a restaurant called Seasons 62 that I highly recommend, but make sure you book ahead.
The only problem I have with the Hyatt is as follows:- Super slow lifts; a shower recess with no soap holder which is great if you don't have a sore back; why don't upmarket hotels provide toilet brushes?? - anyway that's my thing.
I would stay here again when in SD. ps, join the Hyatt Club for free to get the WiFi free.