Hotel is minutes from the airport. Taxi was $13. Hotel has a shuttle and were quoted $16 for two people. Taxi to the zoo was $15. Hotel was next to the Redline and were able to get an all day pass for $5 each. Additional all day passes were less because you first have to pay for the card (I think the card was $2). Two stops to Little Italy and 5 stops to Old Town.
Across the street is Kansas City BBQ. A dive bar with excellent BBQ, cheap beer, and was seen on Top Gun. We were able to walk to the Gaslamp District for dinner where there are restaurants and bars from casual to black tie. Seaport Village is located immediately behind the hotel, which is a variety of shops and cafes/coffee shops/desserts. The Convention Center is a 5 minute walk.
The USS Midway is within walking distance. As is Petco Park, home of the Padres.
The hotel cleaning staff was excellent. I requested a few toiletries on a comment card and all was delivered. Our window looked over the pool and fire pit area. We were able to see the harbor, but not the sunset due to the other tower of the hotel unfortunately.
Hotel has a coffee shop with some breakfast and snack items, as well as several restaurants. We only went to the coffee shop which I would liken to a Starbucks.
Overall, we were happy with the hotel. Didn't spend much time there due to exploring the city in between business meetings. In my opinion was overpriced, however. ($289/night was the discounted group rate).