We spent 6 nights here in November 2012 and were very pleased with the hotel and the location. Fishermans wharf is tacky and unattractive generally, but this hotel is far enough away that it's not a problem. The room we had faced the courtyard, so had no view, but was really quiet and this would be our preference again, as there is not likely to much of a view even from top floor. The room was very clean, including the carpet (always a real turnoff for me - why don't more hotels have wooden floors if they are not prepared to re-carpet more frequently?). Comfy bed, fridge, coffee maker. Nice, if compact, bathroom, with bath. Each evening the wine reception runs from 5-6 with good Californian wines and a snack (free). Sitting by the fire and chatting to other residents after a day out is a pleasant experience. Tea and coffee available each morning too, though not necessary as good coffee can be made in the room. All staff helpful and friendly. The hotel is close to various means of transportation. Both Cable car lines are nearby of course, but also the wonderful F line streetcar, which runs along Embarcadero and down Market street, all the way to Castro. It's $2 or 75 cents for seniors. Buses also available to get downtown or around town. Walking is our preferred way of getting round cities, but in SF you will find the hills a bit challenging, and its useful to have the public transport option. nearby the hotel are a couple of supermarkets to buy food. The hotel has an attached (Italian) restaurant. Again, not our usual option to eat in hotels, but this seemed busy with non-residents and had an interesting menu, so we gave it a try, and we're not disappointed. We had some of the best food of our US trip. if you arrive from the airport by BART, you can get off at Embarcadero station and get the F streetcar to within a couple of hundred yards of the hotel.

Tuscan Inn was great. The room (321) was extremely quiet, clean, and the bed was very comfortable. We spent 8 days vacationing in San Francisco November 2012 and this hotel was close to public transportation, wharf restaurants, Safeway, Cleaners, Piers 41-43, and had great food in the downstairs restaurant.

I have stayed at the Tuscan several times due to its location to a doctor I see from time to time.

Pros:
Great location to Fisherman's Wharf, Coit Tower, Ghiradelli Square, etc.
Very nice and helpful staff
Nice happy hour with free wine from 5-6 each evening
Quiet
Clean

Cons:
No gym. They offer a $12 pass to the 24 Hour Fitness across the street, but I was NOT impressed with that gym. Old equipment and WAY overpriced!

Overall, I would recommend the Tuscan Inn!

We have been guests at the Tuscan Inn at Fisherman's Wharf for over 20 years. We usually make it there twice a year. It is clean, the service is excellent, the resturant is very handy and serves delicious food. Marlow, is the best waiter we have ever had, he works the dinner shift.
The Tuscan is very close to the wharf, cable cars, Pier 39, The Market Place, and many other places of interest. We have stayed a few other places in SF, but always go back to the Tuscan. From the Tuscan we can drive very easily over the Golden Gate Bridge, out to the Cliff House, Marine Headlands and Point Bona Vista. We drive over from Reno, NV. that way we can go to many places of intrest. Wouldn't stay anywhere else in SF. Also, the wine hour is very interesting, to, enjoy wine and good company. Also, to watch the people, you meet all kinds.