I have stayed at the Tuscan several times due to its location to a doctor I see from time to time.

Pros:
Great location to Fisherman's Wharf, Coit Tower, Ghiradelli Square, etc.
Very nice and helpful staff
Nice happy hour with free wine from 5-6 each evening
Quiet
Clean

Cons:
No gym. They offer a $12 pass to the 24 Hour Fitness across the street, but I was NOT impressed with that gym. Old equipment and WAY overpriced!

Overall, I would recommend the Tuscan Inn!

We have been guests at the Tuscan Inn at Fisherman's Wharf for over 20 years. We usually make it there twice a year. It is clean, the service is excellent, the resturant is very handy and serves delicious food. Marlow, is the best waiter we have ever had, he works the dinner shift.
The Tuscan is very close to the wharf, cable cars, Pier 39, The Market Place, and many other places of interest. We have stayed a few other places in SF, but always go back to the Tuscan. From the Tuscan we can drive very easily over the Golden Gate Bridge, out to the Cliff House, Marine Headlands and Point Bona Vista. We drive over from Reno, NV. that way we can go to many places of intrest. Wouldn't stay anywhere else in SF. Also, the wine hour is very interesting, to, enjoy wine and good company. Also, to watch the people, you meet all kinds.

We reserved this hotel as a place to stay while we came to SFO to celebrate our Wedding Anniversary. The hotel is within walking distance of everything and in a good neighborhood.
We stayed in Room 201 which was a nice, but small room. The staff was VERY friendly and the hotel was very clean.

I would not hesitate to stay here again

Stayed six nights. Great location and wonderful company during evening wine. Staff was great and very accommodating. Hotel near cable cars, trolleys and bus lines. Easy walk to anything we needed and to Pier 39 and other attractions.