Our most recent visit to SF was our third. We've stayed just outside of town, downtown (Market Street) and Mission. On future visits, we'll definitely come back to Mission. The highlight of this trip (our first with a baby) was the walkability of the area; everything you need is within walking distance - shopping, restaurants, sightseeing. We walked as far as Westfield Centre one day, and over to Castro the next. From the Castro, you can also take cable cars to many other attractions; we'll make use of this on future visits.
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