As Lexington has grown the number of hotel options has also grown, and you can find most chains within a couple of miles of downtown. That's a good thing. However, the Hampton Inn Col Alto is one of the best. Clean, comfortable, bit of history tied to it. If you want to be close to town this is a good one. There are higher end inn in town, but according to some reviews they are getting a bit tired (not a personal observation). The Hampton Inn has been around seemingly forever but it is not tired or dated. Highly recommended.