Four of us went to Penn Brewery on a Wednesday night. We arrived about 830 and a decent--if loud--small German band was playing.
The food was good, not great, and the wide array of housemade beers (10 in all) were drinkable but not particularly memorable.
A couple things; if a band is playing (and they have music regularly) it will be very difficult to carry on a conversation. If the focus of your visit is food and camaderie, then you may wish to look elsewhere. Second, don't plan on a late night. At 930, we were informed it was last call...while their website says the serve 'til midnight. It was quiet in the restaurant, and my guess is that the staff just wanted to call it a night.
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