I spent one night in Minneapolis on business and found the W to be a great option.
The hotel, located in the iconic downtown building, feels impressive as soon as you walk in. The lobby area is very large, and offers many different spots to meet and hang out, without being too loud. The bar area is spacious and provides a good meeting spot for a quick drink with colleagues.
The staff was very helpful, offering advice on getting around in Minneapolis. Check-in was quick and efficient. My room was tastefully decorated, with a modern feel. It was somewhat on the small side, but I prefer and nicely-done small room to a badly-done large room. Comfortable bed, flat screen tv, large windows, big shower area ... it has just about everything a business traveler is looking for. Given the layout of the tower, there aren't that many rooms on each floor, so the hallways are very quiet; you won't hear a constant flow of people coming and going. I actually never ran into anyone on my floor.
I used the treadmill downstairs at the gym. It was absolutely fine. A good hotel gym with a few treadmills, and some resistance machines.
The location is great for a business traveler. I was able to walk to all my meetings and get a good feel for downtown Minneapolis.
If I'm ever in town again, I will stay there.