I was bitten by bed bugs on my first night of stay. Having been bitten by bed bugs before, I inspected the mattress and found 3 bed bugs. I immediately requested for room change. It was 4am then, and the hotel staff on duty responded promptly, although he doesn't sound apologetic for my inconvenience.
I stayed in the new room for the next 3 days. The new room is OK, no bed bugs found.
The location is out of the way if you don't drive.