The Wrigley building is iconic and I hope it keeps it's name, unlike other buildings in Chicago. It is right along the Chicago River and starting North Michigan and the Magnificent Mile. If you doing any sight-seeing, it will be hard to not walk past it but many people don't take the time to look up at the beautiful buildings and architecture. You can also walk through the bottom part of the building and go into the center for great pictures so check it out when you are in Chicago.
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