We recently spent a week at Alexander's in Key West. It is by far the nicest gay/lesbian guesthouse I've experienced. The entire staff, including front desk, housekeeping, and bartenders were extremely friendly and helpful. They went out of their way to make sure we enjoyed our visit.
I loved our room, which had French door that led to the pool, hot tub, and deck. From talking to other guests, I don't think there's a "bad" room in the place. Some are larger, some are smaller, and some offer more privacy, but everyone seemed very pleased about their rooms.
The atmosphere, at least the week we visited, was extremely friendly. All of the rooms were full, and everyone congregated around the pool at happy hour. Many people chose to have dinner or visit local attractions with others people they met at Alexander's, but if you want to keep more to yourselves, that isn't a problem either.
We heard several times from Key West merchants, taxi drivers, etc. that Alexander's is definitely one of the best places to stay in Key West. I'd agree.
This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC.