Over the last 15 years my wife and I have stayed in lots of places in Key West, but the Southern Cross is the one we keep coming back to. For the price, location, cleanliness and friendliness it can't be beaten.
Last year we stayed 5 times! right in the heart of the Key West fun, there are several options for rooms, from the cheap and cheerful to mini suites.
Bear in mind this is Key West, so if you are used to the big chain hotels the rooms will be smaller, but remember - location, location, location.
Renner the manager treats you like family and will organize anything for you. Whether you are in town for sightseeing or fun in the bars this is the perfect place.