I looked everywhere online for a hotel that would accept us for one night on a weekend and consulted my Lonely Planet as a last resort. Mourelatos was recommended in there and when I called they had space, too!
We've already been back at this hotel and it has become our staple. The building is newly renovated, the rooms are spacious, there is a fridge, microwave, large bathroom, tall ceilings and lake view.
The hotel is kind of pricey, but if you want a relaxing weekend in Tahoe, this is totally worth it.

CONS: no breakfast offered; no online reservations.