From reading the reviews here, I decided to pay the extra and book an ocean view room with a balcony. I wasn't at all disappointed, and the room was absolutely stunning. Binoculars in the room was a nice touch. Expensive, but worth the extra if you can. I don't think I would have enjoyed my stay anything like as much in an internal room.
Location is excellent - short walk to Fisherman's Wharf or Cannery Row.
All the staff were very friendly, from the valet parking guys, through housekeeping.
The only downside was that each night the bar and common areas were busy with corporate types having meetings. Not really what I expected at a resort style hotel/spa in a seaside location. Also I found it strange that the public could just walk into the plaza and use the facilities, which probably explains that not once could I find somewhere to sit down. On one occasion we ended up leaving the hotel to walk down Cannery Row to the Intercontinental to get a drink, and when we couldn't get a dinner table (in a reasonable time), we headed down to Fisherman's Wharf. Basically folk paying $500 per night get no preference over the public walking in. This annoyed me, so feel I must drop a star on the review.
We didn't use the Spa facilities, but they did look very extensive.
Overall, it was a lovely stay, and I would definitely recommend for a short break.