On business, have stayed a few times at another national brand highly ranked hotel in Athens. This time, I chose the Hampton Inn. Considering both are categorized as mid-range hotels, I expected them to be pretty much the same. What a surprise! The Hampton Inn is much nicer. In fact, I think it's safe to say it's by far the nicest hotel in Athens.
Room is large, clean and well appointed, with a Microwave and Mini-Fridge in my room, though not sure rooms are equipped with those. Tastefully furnished, with a comfortable seating area, a large flat screen tv and plenty of room. I was in a double/double room. The room had very much a "clean and fresh" feel.
Staff was exceptionally nice and helpful. Breakfast room was clean, and nicely appointed, although the breakfast was a little hectic. Complimentary USA Today in lobby, as well as local papers.
I overnight in Athens once or twice a month, and without doubt, this is now my overwhelming first choice.