If you are looking to walk out of your hotel and find yourself in Osaka party central...then this is NOT the hotel for you. If you want to spend a day anywhere in Osaka and return to peace, quiet, and a great selection of restaurants...then this is probably the hotel for you. Hyatt Regency Osaka is located in the port district of Osaka, as stated by most of the reviews on here, and is about 30-40 min to downtown via the hotel shuttle. However, you are a 5 min walk from either Nakafuto or Trade Center Mae New Tram stations. From either station you can reach anywhere in Osaka. So, the hotel may be isolated, but the city is highly accessible. Get a Kansai Thru Pass (for tourists) or a PiTaPa (similar to Tokyo's Suica/Pasmo) train pass. Suica will actually work in the Kansai region. Or really learn the subway/train system by purchasing tickets at the machines...press English first.
From Trade Center Mae you pay 200 yen (adult, half for children) to reach Osakako Station, where you get off and walk five minutes to Tempozan Village. There you can ride the Ferris wheel and visit the Kaiyukan Aquarium (highly recommended). If you stay on the Chuo Subway Line to Bentencho, take the Osaka Loop Line (clockwise) to Universal City Station and enjoy the day at Universal Studios. Beyond that, public transportation will get you anywhere else you might like to go.
We were in room 621 (Club Deluxe Twin), an 80 sq meter corner room that was very impressive in size and amenities for a Japanese hotel. It felt like a suite with plenty of room and furniture to stretch out. Wi-Fi was available in-room and was a pretty good speed (Speedtest.net tested at 20Mbps download/upload and that was pinging a Tokyo server). The shower was very large with fantastic water pressure. Being a corner room, the walls were all windows with a nice ledge running the entire length of the room in order to sit and enjoy the view. We could see the Tenpozan Ferris wheel and Kaiyukan Aquarium from the room. Regency Club is nice (on 26th floor) but call ahead for a table because it is popular. Be advised though that the food is the finger variety and is great for pre-dinner drinks and snacks. The Regency Club staff made other restaurant reservations for us at The Cafe (buffet) and Basilico (Italian). The Cafe is standard buffet with a good spread, but nothing terribly special if you frequent the hotel buffet. Basilico was excellent and we were able to take advantage of the New Year's set menu for 5000 yen that was a deal since everything you got was twice the price a la carte. The food was of excellent quality and the drinks were fine. The Lobby Lounge also has a nice breakfast and afternoon tea spread for a resonable price and children were free at The Cafe buffet and The Lobby Lounge service. Service throughout the hotel is classic Japanese...very sharp and all smile.
Finally, we took the Shinkansen from Shin-Yokohama to Shin-Osaka. Transfer to Osaka/Umeda Station (same station, Osaka refers to JR Line, Umeda is the subway). Exit out Sakurabashi Gate and you will see the shuttle bus stop with attendant. The bus leaves every 30 minutes and you don't need a reservation. It takes about 30 min to reach the hotel. They also have a shuttle that will take you to Cosmosquare Station as well. Their business center sells tickets for Universal Studios, but it is cash only.
We might try the Hilton Osaka next time for the variety, but would not hesitate to stay at the Hyatt Regency again.
This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC.