Stayed at the wonderful Casa Arequipa in May 2012. We loved every aspect of the experience, the decor, the rooms, the incredible breakfast, and the general ambiance. I think what I enjoyed the most was the walk from the city center, I loved getting to know the streets of the neighbourhood and feeling like I was a local in Arequipa.
But the real gem of this hotel, as mentioned by many othes , is the staff. They got to know us by name, and part of the fun was chatting with everyone that worked at Casa Arequipa at the beginning and end of the day. They took care to safely put us in cabs (always jotting down the cab's number "just in case") and helped with any request be it big or small. Silvana was always smiling and so kind to us. However, I think the "piece de resistance" was when Snr. Damasso offered, ever so graciously, to walk to Puente Bolognesi with me to help me buy a charango (small Peruvian guitar) for my brother in law. It was really above the call of duty and I really appreciated this gesture.
If you like staying at small boutique hotels that are anything but cookie cutter, this is the hotel for you!