We stayed 4 nights in Mid-September on our first trip to Turkey. Overall the hotel was great, although the traffic to get back to the hotel was annoying. After a wonderful buffet breakfast on the terrace on the Bosphorous with clear views down to the Sulthanamet we'd leave around 10, grabbing plentiful taxis to Taksim for around TL10. Returning around 6 was like trying to get into Manhattan, it was faster to walk. There's no tram to the hotel, it stops about a 30 minute walk away. There are no ferries either. If you've been walking all day save some energy for this walk. We even had some taxis refuse to take us, I assume because of the traffic, but of course since they don't speak English we never figured it out.
From Taksim you can get good public transport or take the hop on/off bus. The bus was not working for us as it stopped too long at monuments, every time we went to reboard it would not be leaving for another 30 minutes. So we'd wonder off to get a beer and return too late invariably waiting for a check that never came. In fact I would say patience is a virtue in Istanbul.
The area around the hotel has everything you could want in nightlife, so really why bother leaving. You have very high-end restaurants around as well as affordable eateries. The breakfast buffet was very complete. We had it 2 days. There's a bunch of smaller eateries around like Kitchenette that had great coffee and croissants and deserts at night. There's a large pedestrian area that extends from the hotel door to the bridge with shops and restos. We tried Ferriye's next door and it was a beautiful place but the food disappointed. I asked for a medium filet and it arrived way too fast and undercooked. It was only 9PM and they were anxious for us to leave. We did a dinner cruise on the Transtur which although the food wasn't great the entertainment and experience made it great and memorable. The boat stops at a nearby dock (200 yards) to board and return you so you don't have to deal with transfers to the dock.
The room was very well equipped. The bed and sheets were excellent. The rain shower had such great pressure you didn't want to get out. There was some noise if you face the alleyway where the front door is. There is Anjelique right outside and it goes to late as does Zuma and the partygoers, their cars and limos aren't concerned with their noise. If you want to be on the Bosphorous and the Ciragan is not in your budget, the Rad Blu is a good choice.
BTW I'd recommend a car and driver you can hire at the airport for I think around E50, much more comfortable for the long drive and the driver was gracious to point out the sights. Also the Ortakoy mosque is under renovation and comlpetely covered.