This hotel is located in he CBD about a 5 minute walk from Flinders st station and 10 minutes walk from Southen Cross Station. It can be quicker to walk than to wait around for a skybus shuttle if you don't have a lot of luggage.
The hotel itself is easy to find. Reception is not on street level but you can leave your luggage here when checkling in or for pick-up later. The foyer is modern with an open view of the shopping mall below. The rooms are spacious with good color schemes, neither tame or lame. The bed was excellent. The air conditioning responded quickly to changes ( I haven't seen this in any hotel before). The only issues - the television didn't work and while the staff member that came to look at it arrived promptly, I really didn't feel he wanted to. In the end he couldn't fix it.
Due to its location you'll be able to find almost anything you need close by. Coles supermarket is a 5 minute walk as are fast food restaurants. Trams run from almost in front of the hotel.
One last thing, the CBD goes very quiet at night ( not many people and very little open). I'd be more inclined to stay outside of the city if I was a night owl.