The staff was very friendly and the building is in the shadow of the castle. However my room may be the smallest I've ever been given since I stopped staying in hostels--and I've slept in a lot of small single rooms in Germany. (To be fair, when it came time to check out they did not charge me the full amount of my reservation, because they substituted such a tiny room.) Also be aware that if you are walking from the train station, it will take about 20 minutes.
No English stations on the TV. If I'd stayed more than one night in Quedlinburg, I would have moved to another hotel, probably one that is closer to the marktplatz.