We had a great time at NL-Hotel Museumplein 30th Sept - 4th Oct. It was perfect for a short break. We staying in a deluxe double room on the second floor - no problems with noise, and the room was beautifully decorated. We got a train and tram from the airport to the hotel, but the friendly receptionist advised us to get a bus back - this was only 30 minutes from just outside the Concertgebouw (which is 2-3 minutes walk away) and only 3.90euro so if you want a cheap and easy route to/from the hotel-airport, go for the bus!
Very close to the Vincent Van Gogh museum, Concertgebouw (go on Wednesday at 12:30 for a free show!) and the Rijksmuseum. We are a young couple in our twenties, but felt safe yet central - can only be a good thing! Back to the hotel - clean, friendly, comfortable - only 5-10 minutes walk and you're in the centre near Leidesplein/Remembrandtplein. Would recommend to anyone.