I recommend. centrally located, clean. The neighborhood can get a little loud, given that it is centrally located - so bring earplugs. Stayed a couple of nights during the [hot] summer.
Make sure you have a map and know where you're going if you arrive via train, otherwise the hike from the bus stop can be somewhat oppressive if you're trying to lug your suitcase through the cobblestone streets.
The restaurant downstairs (not affiliated with the hotel) happens to have a great wild boar pasta and good wine selection. Value for money during the high season, it was a solid choice.