I wholeheartedly recommend Relais Sassetti Bed and Breakfast. We stayed four nights in the Lions Apartment, a a clean, spacious, and comfortable dupleix with a kitchen corner. The location is amazing: in the historical centre, 10min walk from Pisa's central station and 10m from the Leaning Tower, close to many good restaurants. Simona, our host, was very helpful and friendly. Giving advance notice of my dietary requirement made it possible for her to provide me with a gluten-free breakfasts - wonderful! It also turns out that Simona speaks French well - a treat for us. I enjoyed the experience of staying in an old palazzo, with its high ceilings and thick walls; our son enjoyed spotting the two tortoises in the courtyard and being allowed to play table tennis. The thick walls made the internet connection often go weak, except close to the windows or outside - fortunately that was not a priority!