We spent 5 nights at the Laurus al Duomo and would strongly recommend it. Really good value for money (we booked with Expedia), clean and comfortable. The hotel is a short walk from the main station and only a couple of minutes from the Duomo. We were on the top floor and had a great view of the Cappelle Medicee and San Lorenzo from our window. One floor below us was the breakfast room, which also had great views. Plenty of choice for breakfast.
My husband found the bed a bit firm, but that is a personal thing. The room wasn't large, but fine for a few days. Despite being in the centre of the city, we did not find it noisy at night.
We would definitely recommend this hotel to friends.