We recently stayed at Palazzo Guadagni which is located right in the heart of Santo Spirito. The location is perfect - it is buzzy with lots of nice local restaurants and bars, whilst not being directly on the tourist trail. The centre is easily within walking distance from the hotel and you can take in the beautiful Arno on the way over. We were greeted by the charming Martina who was on hand to recommend local places to eat/drink etc.. The views from the hotel are exceptional and the rooms beautifully appointed with just the right balance of charm and authentic Italian decor. Great value for money also.