Palazzo Guardi was an excellent choice of hotel for me. The neighborhood is very quaint compared to the rest of Venice, from my experience, which I enjoyed. The staff was very helpful, especially a young man named Nico, who spoke perfect English and helped me map out a route to San Marco square. As for cleanliness, the room was one of the cleanest rooms I've ever stayed in and very cutely decorated. The elevator is a little tricky to use, especially if you check in at night (the lights go off on a timer at night, and you can get "stuck" in the elevator in the dark if you don't read the instructions properly. Basically, you hold button 3 continuously until the elevator stops on its own, and the exit door for the elevator will be on your LEFT if you face the entrance to the hotel. Other than this minor factN as a woman travelling alone, I felt very safe in this neighborhood and also loved how quiet and authentic it felt compared to San Marco area. If I return to Venice, I would stay here again.