There are a lot of hotels to choose from in Venice, but you would be hard pressed to do better than the Palazzo Sant' Angelo. Incredibly friendly and helpful front desk staff, excellent Sestiere San Marcos location on the Grand Canal next to a Vaporetto stop in basically the center of Venice.
Our Junior Grand Canal Suite was spacious with a beautiful bathroom, walk-in closet/depressing area and a nice sized bedroom with glass doors opening onto small balconies overlooking the Grand Canal. The Rialto Bridge is visible in the view to the right. A small buffet breakfast is included each morning. You are within a 30 minute walk from just about anything in Venice. I was a little concerned about the possible noise level on the Grand Canal, but the room was actually pretty quiet. The only downside I saw is the lack of free WiFi, it is available but fairly pricey.