This was our third visit to Ca'Pisani - it continues to please and for Venice deliver great value.
Yes, it was the first "design hotel" in Venice - opened in 1999 or so - but it's aging very gracefully. The baths still look and function extremely well. The mix of deco and contemporary is stylish and doesn't look dated (traveled with 2 high-end designers who agreed). The building is beautifully restored. The owners have great art from the 20's to the present.
Some ding the staff. I can't agree. The front desk team is professional and charming (with low turnover), the housekeepers pleasant and through. The breakfast staff does seem to turn over, so they can get a little overwhelmed in high season.
Unless you want to be overwhelmed by day-trippers or on the water, the location is perfect. Just behind the Accademia - so you are convenient to multiple vaporetto stops, about 20 minute walk from St. Marks and virtually no one ventures past the Accademia, therefore, it's a quiet, low-key and extremely pleasant place to sit outside for b'fast or a drink.
Finally, for Venice I find it fairly priced compared to similar properties.