My wife and I just got back from our trip to Italy (First trip to Europe). We stayed 2 nights in the Pantalon Hotel. This was part of a package deal. We arrived via train to the main station. We took a Vaperto to the San Toma stop. This is best way to get to the hotel. It is pretty cheap 5 euro each and you get a great welcoming view of the grand canal. Finding the hotel is a little tricky, but just ask around and you will find it. The venitian people are very helpful. The addresses are a little confusing, Dousdouro is not a street, but an area, so you have to keep walking around till you find it. The numbers go in one direction (took a while to figure out), but that helps. Room was incredibly small. We had a double, which was a twin bed with a twin cot in the corner. Entire room, including bathroom was about 100 sqft. Although, after reviewing fire diagram on door, I figured out we were in the smallest room on the floor. Others were not as small. Anyway, room was clean and worked for us and we not in it that much. Hotel is relatively centrally located, mainly because venice is so small. Breakfast was rolls and coffee and drinks and was more than adequate. Staff was very helpful and courteous. We asked about the best way to get to Murano, and the staff informed us they would get a free water taxi to the island to see the glass factories. This taxi took us directly to a factory dock, where they ushered us in to see a demostration for a few minutes and then to the showroom to buy something. We are very into glass sculpture so we purchased some glass, so they paid for the water taxi back the San Marco for us. Otherwise I think you need to find you own way back, which would be the vapereto. There are enough restaurants within a 5 minute walk, and all were nice and served good food. Getting back to train station can be via the vapereto again, or you can just walk. It is a pretty straight shot and is only about a 15 minute walk (3 bridges). You then take a bus to the airport (3 euro). Check schedule at hotel to time this correctly. You can do this when you arrive too, but view from vapereto was very nice and gives you a good sense of venice right away. Overall, hotel is pretty nice, very small, but cute. Again this was part of a package and had everything we needed.