We stayed at Le Isole for 3 days and thoroughly enjoyed it. Our room overlooked the canal and was a good size for Venice. The complimentary mini bar was a boon and always meant we had cold water to drink.
The staff were extremely helpful and pleasant and the young lady who served and made breakfast was delightful. The breakfast was very good and had far more choice that I would expect have travelled on business for many years.
The location was great - a few minutes walk from San Marco. A tip to find the hotel - it is literally behind the Danelli and over the canal.
I couldn't recommend Le Isole more highly and would go there again in a heart beat.