We have just stayed at Hotel Le Isole in Venice and it was excellent.
Good value for money, I booked in November so its off season, but even so we thought it was well priced for the room, service, location etc.
Hotel is very close to St Marks square. We made the mistake of putting the street name into Google maps. DO NOT DO THIS. It gives you the wrong location and we got off at the wrong stop and then got lost. Use the map on the hotel website. The easiest way to get to Hotel Le Isole from Venice St Lucia Railway Station is get on the Vaporetto Line 2 at Ferrovia and get off at either San Zaccaria or St Marks. The one way tickets are Euro 7 so its worth getting a 12 or 24 hour ticket as they are more economical. The Rialto Bridge is only about 10-15 mins walk from the hotel, but venice is a complete maze so expect it to take longer the first time.
When we checked in the management was very nice to us, and later when we came back to reception they were very helpful.
Breakfast is good quality, wide range of options, runs until 12 noon (!) and the lovely woman in charge makes you fresh coffee (Latte, cappuccino etc), whatever you request.
The Economy Room was small but perfectly formed, has everything you need, bathroom was nice and very clean. Windows look out onto a busy street but must be either double or triple glazed as we heard nothing at all. Church bells from San Zaccaria are also close and chime during the day and presumably the night, but again we heard nothing once in the room.
Overall very good hotel. No complaints.
This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC.