We found the location to be perfect. It is on Dorsoduro on a quiet side canal within sight of the Grand Canal. The Accademia is just a block away so you not only have the vaporetto stop there, you also have easy access to San Marco via the Accademia Bridge and all sorts of directional signs leading you "home" as you wander through the city.
The staff was wonderful, handling our luggage, offering recommendations, making dining reservations, and greeting us each time we came and went. Breakfast buffet was lovely with a different, delicious pastry as the highlight each morning.
Each room was somewhat different; I saw a few of the other rooms and found some of them to have the windows in unusual arrangements. The hotel consists of two buildings joined by a short walkway so some of the rooms will look across the narrow open space to the other building. Although each room seemed fine, I definitely recommend a balcony room. Our room had three French balconies--two overlooking the small canal and one facing the Grand Canal. There was a street light attached to the wall just outside one of the balconies but the light went off at a reasonable hour. You will hear the garbage and the mail boats going about their work in the morning, but none of this seems to start before a decent time.
The bathroom seemed newly redone and had all the amenities, but because Italian bathrooms are often small to start with, it was cramped.