I stayed at the American Dinesen last July. It´s a great place to stay, as it´s located near the Ponte dell´Accademia, far from the noisy Canareggio and Rialto. San Marco Piazza is walking distance (about 10 min). The Peggy Guggenheim museum is just around the corner, as well as the Accademia Gallery, both have a collection of amazing pieces that are worth seeing. Rooms have a reasonable size, especially if you consider the tiny scale of Venezia. The beds are comfortable and the neighborhood is quiet so you can definitely get a good rest after a touristy journey. Breakfast was good, too. There is no elevator, but they would help you out with the luggage through the stairs. Personnel are friendly and always willing to help. I definitely recommend it.

This charming small, quiet hotel is in the best location in Venice, on a small lovely canal off the beaten path in Dorsoduro. Far fewer tourists are seen in this area and it seems more the real, delightful Venice of times long past. All parts of Venice are easily accessed from here by foot or with vaporetto assist. This beautiful sestiere has several good restaurants and lively Campi ( like Santa Margherita). The staff of the hotel is very friendly and helpful. The rooms are medium sized, fully adequate, attractive, and have all amenities. Breakfast is more than adequate. My wife and I will, hopefully, stay here again!

Myself and my wife have just spent a wonderful four nights in this superb small hotel.
I dont like to book in advance because I like to see what I am getting before settling on a room. So last friday afternoon at sunset we arrived by boat from the airport, hoping to find a gem.
I left my wife at a cafe with the bags and set off to check out as many hotels as I could find in the area.
This was the third that I found, and even though it seemed perfect I managed to have a look at rooms in another four hotels before settling for this one.
The reason being that of the seven I saw it was by far the nicest room and the second cheapest.
It actually felt like more of a suite than a room, as it had two balconies one facing the Grand Canal, the othe overlooking the canal directly outside, beamed vaulted ceiling loads of windows and a huge bathroom.
Room302 top floor. Fantastic.
Great staff, very good buffet breakfast and views to die for.
Worth the cost to make our stay in venice feel so special.
I will also post a photo of the room to prove that I am not exaggerating.

This was our second visit to Hotel American Dinesen - the first being eleven years ago. It was as good as the first time round. Our canal view room was spacious and clean and all the staff were extremely polite and helpful. The hotel is perfectly situated for sightseeing but in a quiet location. We shall definately be going back, in fact we would never stay anywhere else in Venice.