Location: the Duomo is 8-10 Euros away by taxi, or 15-20 minutes by tram, can go their by foot too, it is in walking distance. Street is quiet.
Room: don't expect a huge one for this price, but it is comfortable. Air-conditioning, comfortable beds, TV with hundreds of channels, bathroom with bidet.
Service: helpful and friendly staff, always were ready to answer my questions about directions and shopping, etc. Cleaning lady did a perfect job, too.
For me the clean room and helpful staff are number 1 priorities, so I would happily come back here in the future. Highly recommended hotel.