The Vatican museum is certainly the best I've ever been to. It's worth both the time and the money you will spend to see it! Go as early as you can before the crowd builds up. We did the guided tour as we couldn't be bothered to waste half a day standing in a line. It's worth the few extra euros.
The museum is immense and spells grandeur. There's so much to take in you can hardly manage it in a whole day. But do go there... What's the use of traveling all the way to Rome and not visiting the Vatican. You'd have to be crazy to not do that, right???
Point to note -- If you go there on the last Sunday of the month, entry to the museum is free.
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