This was a perfect location for us. The B&B is in a condo building so it feels private. No big signs of hotel or anything. It is in a residential area.
the service was fine, except the reception guy gave us the wrong info on the vatican museum, causing us to miss our visit on the free day. We had breakfast in our rooms everyday (part of the deal) and that was great. we also loved the italian music channel on tv. the room was wonderful and designed to make the most efficient use of its space.
One tip, do not eat at nearby Piazza Cavour. all the bars/restaurants in that area have bad service, very expensive for the low quality food, hidden cover charges, beverage prices not listed (and ridiculously expensive). we stayed in this area for 5 days and experienced (or witnessed) the same problems at 8 different places there.

We spent a full week at the Residenza and had a wonderful time. The rooms was impeccably clean and the service outstanding. The room is small but that is the norm for Rome. Besides, we were hardly ever in the room as our intent was to see the city. The Residenza provides a private oasis on a quiet street. The location is actually ideal as it is within easy walking distance of the Vatican, Piazza Navona, and it is very close to the metro which can get you virtually anywhere you need to go.

We met up with a bunch of friends in Rome and booked out 5 of the 6 rooms that this lovely little hotel has. Great location not far from Lepanto train station and just up the road from the Vatican as the name suggests, with some really good shopping in the main road a block away. Note that the two back rooms are the largest, although all bathrooms are small as is the norm in small hotels in Italy. Rooms are serviced daily and are clean, quiet and very comfortable with good air conditioning. They do not take credit cards so be prepared.

Don't do the Vatican tour that is advertised in the brochures at the hotel however. It cost 45 euros a head (it only costs 12 to get into the Vatican) and we thought we were going on a small tour which was confirmed when a mini bus picked us up at the hotel in the morning. Silly us, the small bus took us to the tour company's office and we were then loaded onto a massive bus with 50 other people! We then stood in a queue for over two hours in the baking sun and were herded around like sheep. Ripped off.

We would have been much better going directly to the Vatican (we could walk to it from the hotel) later in the day when the queue is much shorter, paying our 12 euros and wandering around ourselves. It's not worth standing in a queue for two hours, even to see the Sistine Chapel, where you wonder why you're doing the right thing and not taking pictures or talking loudly, when everyone else is.

The room was very very small, with the door right next to the B&B entrance, so that we could hear other guests coming in all hours of the night. I have never in my life seen such a small shower stall. The cleaning person threw out some personal toiletries. And you better not be thirsty- you will be charged 3 euros for bottled water from the fridge. It is not as close to the Vatican as one would imagine of a place named Residenza Vaticana. The welcome was nice, as was the lady that served breakfast, but altogether not a pleasant experience.