We totally loved our stay at the Residenza Vaticana in March 2007. Booking was through Romeby.com, and although it was a bit pricey for our personal budget ($120), I was extremely satisfied. Upon our arrival, we learned the owner/manager had generously upgraded our accommodations, transferring us to their newly opened rooms just a few blocks away. The rooms are on the 3rd floor of a very well maintained and secure building. The entire floor occupied by the inn was very plush and well decorated. Everything is new and amenities are modern. Customer service (i.e. reception, information desk, house keeping, breakfast service, etc.) was great, the staff was always eager to please. Location was very convenient to local shops, the Vatican area and railway system. The inn is situated in a calm neighborhood of shops and buildings, less busy compared to West of the Tevere. During our stay we had to pay cash because the manager was still arranging credit card services, as this truly was a newly opened facility. I would highly recommend this inn for its location, comfort, luxurious amenities (-using European standards) and kind management & working staff..

This was a perfect location for us. The B&B is in a condo building so it feels private. No big signs of hotel or anything. It is in a residential area.
the service was fine, except the reception guy gave us the wrong info on the vatican museum, causing us to miss our visit on the free day. We had breakfast in our rooms everyday (part of the deal) and that was great. we also loved the italian music channel on tv. the room was wonderful and designed to make the most efficient use of its space.
One tip, do not eat at nearby Piazza Cavour. all the bars/restaurants in that area have bad service, very expensive for the low quality food, hidden cover charges, beverage prices not listed (and ridiculously expensive). we stayed in this area for 5 days and experienced (or witnessed) the same problems at 8 different places there.

We spent a full week at the Residenza and had a wonderful time. The rooms was impeccably clean and the service outstanding. The room is small but that is the norm for Rome. Besides, we were hardly ever in the room as our intent was to see the city. The Residenza provides a private oasis on a quiet street. The location is actually ideal as it is within easy walking distance of the Vatican, Piazza Navona, and it is very close to the metro which can get you virtually anywhere you need to go.

We met up with a bunch of friends in Rome and booked out 5 of the 6 rooms that this lovely little hotel has. Great location not far from Lepanto train station and just up the road from the Vatican as the name suggests, with some really good shopping in the main road a block away. Note that the two back rooms are the largest, although all bathrooms are small as is the norm in small hotels in Italy. Rooms are serviced daily and are clean, quiet and very comfortable with good air conditioning. They do not take credit cards so be prepared.

Don't do the Vatican tour that is advertised in the brochures at the hotel however. It cost 45 euros a head (it only costs 12 to get into the Vatican) and we thought we were going on a small tour which was confirmed when a mini bus picked us up at the hotel in the morning. Silly us, the small bus took us to the tour company's office and we were then loaded onto a massive bus with 50 other people! We then stood in a queue for over two hours in the baking sun and were herded around like sheep. Ripped off.

We would have been much better going directly to the Vatican (we could walk to it from the hotel) later in the day when the queue is much shorter, paying our 12 euros and wandering around ourselves. It's not worth standing in a queue for two hours, even to see the Sistine Chapel, where you wonder why you're doing the right thing and not taking pictures or talking loudly, when everyone else is.