I stayed in Hotel Scheppers for three nights with my husband. We did not have much time to decide where to stay in Rome and made a last minute reservation.
If you are looking for an inexpensive yet super clean hotel with polite staff I can recommend this place. The staff spoke very good English and were very helpful in giving you advice how to get round the city and find your way back to the hotel :) Even found a similar hotel for us near Florence.
To find the place was little challenging though not impossible. (We used an outdated navigation system from 2002 and that mislead us slightly.)
If you are not the lazy type 5 minutes walking to the nearest bus stop is not a lot. We found public transport is reliable and you can be at any sight within 30 minutes.

Rome. What a place. Beautiful. The people of Rome are fantastic and attempting a little Italian goes a long way. Just a shame that Scheppers Hotel, allegedly 'just a few steps from the vatican' is no where near the Vatican or the rest of the key sights of Rome. This place is virtually on the out skirts of Rome. You'll need to walk 1/2 a mile to get the bus. Then a walk to the tube. Change on the tube. Get another bus and then a little walk. Not just a few steps then. The hotel doesn't handle travellers cheques and the breakfast isn't all that good either. Even the taxi driver didn't know where it was (and they start charging from the moment verbal contact is made). The driver found it by accident because he was turning around in the grounds of the hotel in front of it (The Holiday Inn as I recall). When we got there, the staff were totally disintersted in their customers. My advice would be to book somewhere else, particularly for a weekend break.

We stayed at Scheppers Hotel for one night, since we arrived at Fiumicino Rome airport quite late. It's a nice, simple hotel, wirh clean rooms, tough quite unpersonal. The staff was proffesional and spoke english well.

We had a rental car, since we where to drive to Tuscany the next morning. The hotel was somewhat hard to find. So i would get directions and a map from the rentalcar staff at the airport. (But it's quite close to the airport)

The hotel was actually perfect for a stayover if you're just travelling trough Rome. I would not recomend this hotel if you don't have your own car, or is in Rome for a vacation.

The hotel have its own parkinglot, just on the side of the reception. It's not a closed parking, so I would recomend bringing all your luggage inside for the night.

It was my second time in Rome and my girlfriends 1st.So when we arrived at Aurelia train station we had to walk 1km,then over an overhead bridge then up a steep hill and with all our luggage.We couldn't find the street,let alone the hotel.It was 30 odd degrees as well.45 minutes later we found itand checked in.We went upstairs and went in to the room,if youswang a cat it would definately need a helmet.It was the smallest room i have ever seen.Clean though,(you couldn't put anything in there thats why.)The next day we went downstairs for breakfast.How dissapointing,Buffet breakfast it wasn't.Rubbish is all i can say.The hotel is so far away from anything as well.On a good note,the staff where friendly,the beer was cold and the airconditioning was fantastic.We will be staying closer to the centre next time.