We find the Hotel in an excellent location and the Hotel staffs are very helpful from the moment we arrive.
I will certaintly go back and stay there again if i have the chance to go back to Rome. Is a good location to walk to any part of the city.

We originally picked this hotel as part of a package and weren't sure what to expect. What we found was a hotel 2 blocks from the Termini station, and within walking distance of the several major sightseeing areas. The staff was very friendly, open and helpful (Marco in particular). They were all cheery and warm. The room was average size for a European hotel and very clean. The shower had good water pressure, although the water temperature in the late morning never got as warm as it did at non-peak showering times. The room had large windows with shades and we left them open throughout the day. The breakfast was good but simple fare. We would have come back to the Serena for our last night in Rome if we hadn't already booked another hotel.

If you need to be near the train station and won’t be staying for long, this hotel will suffice. It’s a quick two blocks west of Rome Termini, on the second floor (with an elevator) of an older building in a relatively gritty neighborhood. The room was tiny but clean and fully equipped with refrigerator, safe and satellite TV. The bathroom was larger than many others, with white mosaic tiles, shower, bidet and hairdryer. Hotel staff were cordial and helpful, and there were several internet points within one block. Breakfast was about average, with salami, cheese, croissants and coffee from a machine. It’s hard to find reasonably-priced rooms in Rome, and we thought 140 euros a night was still high for what we got, but we didn’t have any real complaints about the hotel. (However, you could smell Chinese food cooking nearby.) We would recommend Hotel Serena only if you needed an inexpensive place near the train station to sleep for a night or two.

Reading the other reviews on here i thought that this place was not going to be great. I was pleasantly surprised because it was a nice hotel in a good location. There are plenty of places to eat and shop around the hotel. The people there were all friendly and because of this we came back and stayed an extra night there when we got back from Napoli.