We originally picked this hotel as part of a package and weren't sure what to expect. What we found was a hotel 2 blocks from the Termini station, and within walking distance of the several major sightseeing areas. The staff was very friendly, open and helpful (Marco in particular). They were all cheery and warm. The room was average size for a European hotel and very clean. The shower had good water pressure, although the water temperature in the late morning never got as warm as it did at non-peak showering times. The room had large windows with shades and we left them open throughout the day. The breakfast was good but simple fare. We would have come back to the Serena for our last night in Rome if we hadn't already booked another hotel.
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