I recently stayed at Cascina for three nights during a vist to Rome. I had a rented car so transport was not a problem, although central Rome was about a 20 minute drive away.

I would recommend you print a map from Google Maps to help you find the hotel. I found Google Maps had the most accurate and detailed maps for finding hotels in Italy.

This hotel has a lot of character! The layout is a bit strange and the lift made me feel like I was in a science fiction film!

In a nut shell:

The hotel is very reasonable, our stay was £95 (142 Euros) for three nights in a double room.

The breakfast was brilliant, a good choice, very tasty and with plenty of space at each table.

The staff were fantastic, very friendly and helpful.

Secure Parking in underground car park, with lift direct to your room.

Our room was very clean.

If your driving and on a budget this hotel is perfect.

I've been in Cascina Palace last weekend. Paid 80 Euro per night, double room with private bathroom and good breakfast included. For what i paid, it is acceptable, since hotel prices in Rome are VERY EXPENSIVE!

If you don't mind to be 11km distance from the center of Rome and if you are out of budget, this will be ok for you.
First night: everything ok. Arrived at 23:30 at the hotel. No restaurant in the hotel, and restaurants nearby all closed after 22:30. Called for a taxi (10euro just for calling) and drove to a good restaurant called "Torre". Good and cheap. 6 Euro ppp.
Second night: Wasn't lucky since the people from the room next side were making noise and laughting until 1AM. After warning them and the reception, they shut up. Woke up at 7AM with racket of workmanships.

How to get into this hotel:
FROM FIUMICINO AIRPORT
1) Take the train to Termini Station (5 Euro, 30minuts)
2) Take the subway line B, blue line to "Ponte Mamollo" (1 Euro, 20 minuts, direction rebibbia)
3) Take the Bus nr 341 and get out after 5 stops (Galbani Stop) (1 Euro i think, 15 minuts)
4) Walk 2 minuts, turning the first on your left, and you see the hotel cascina palace.
This will take you about 1h15m

HOW TO GO TO CENTER OF ROME:
1) Walk 2 minuts til bus stop.
2) Take bus 341 and get out on the last stop (Ponte Mamollo)
3) Take subway till termini, line B, blue line. (direction laurentina)
4) At termini, just choose were you want to go, you are at 10/15 minuts from everywere, with bus and subway.

The area is SAFE, i walked there at night and no problem. It is a residencial area. Altought, you don't see anyone in the street at night. Very good pizzaria near the hotel.

Staff of the hotel is helpful and speak english.
If i would come here again? It Depends! I reserved this the day before arriving rome. It was a last time reservation. All hotels in rome (center) were full.
If you are booking with some time, you can get better hotels in the center starting €125 per night with bathroom.

hope it helps you!
enjoy!

recently stayed at the cascina palace for two nights on a business trip. not only is the hotel too far out it was awful. the place didn't feel to be in a safe area (having security gates to get in) and also wasn't very clean.
there are much better options nearer the centre.

You need to take a line on the metro to the end and then transfer onto another surface bus to get from the center of Rome to the hotel. Not much to see around the hotel. Rooms were very basic.